摘要
3-乙磺酰基-2-吡啶磺酰胺是磺酰脲类除草剂玉嘧磺隆重要中间体.以乙磺酰基乙腈和1,1,3,3-四甲氧基丙烷为起始原料,经消除加成、取代、环合、硫代和磺酰胺化五步反应合成得到目标产物.质量分数为98.5%,总收率46.5%(以乙磺酰基乙腈计).产物及中间体结构经1H NMR和MS表征确认.
2-aminosulfonyl-3-ethylsulfonyl pyridine was an important intermediate of rimsulfon. Using 1,1,3,3-tetramethoxypropane and ethylsulfonyl acetonitrile as starting materials, it was synthesized by a five-step reaction, i. e. elimination-addition, displacement reaction, cyclization reaction, sulph reaction, sulfonamination reaction. The total yield was 46. 5% and the content was above 98.5 %. The structures of product and intermediates were comfimed by ^1H NMR and MS.
出处
《浙江工业大学学报》
CAS
2007年第5期494-496,共3页
Journal of Zhejiang University of Technology
关键词
乙磺酰乙腈
玉嘧磺隆
闭环反应
ethylsulfonyl acetonitrile
rimsulfon
cyclization reaction
