重症格林-巴利综合征呼吸机相关性肺炎分析

Correlative analysis ventilator associated penumonia in severe guillain-barre syndrome patients

目的:探讨重症格林-巴利综合征呼吸机相关性肺炎的发生机制。方法:对156例重症格林-巴利综合征应用呼吸机者呼吸机相关性肺炎的发生率、发生时间及病死率进行回顾性分析。结果:本组呼吸机相关性肺炎的发生率为36.54%,上机时间越长呼吸机相关性肺炎发生率越高(P<0.05);以假单胞菌为主要病原菌(P<0.01);男女间呼吸机相关性肺炎发生率比较无显著性差异(P>0.05);以≥40岁者呼吸机相关性肺炎发生率最高(P<0.01);预防性应用两种抗生素者较一种和三种以上抗生素者呼吸机相关性肺炎发生率明显降低(P<0.05);发生与无发生呼吸机相关性肺炎者病死率比较有明显差异(P<0.05)。结论:重症格林-巴利综合征患者在年龄、上机时间、预防性应用抗生素种类等方面与呼吸机相关性肺炎发生率密切相关,且发生呼吸机相关性肺炎者病死率明显升高。

Objective：To explore the mechanism ventilator associated penumonia （VAP） of severe GBS patients. Methods： Retrospective analyzed VAP of 156 cases GBS patients accidents attack rate, attack time and moritality. Resolts： 36.54 percent GBS patients acquired VAP. The more opporunity acquired GBS patients , the more used ventilator in time（ P 〈 0.05） ; the most bacterial were pseudomonas spp （ P 〈 0.01 ）, it was the signficant differences between men and women （ P 〉 0.05） ; the most patients were those age over 40 years （ P 〈 0.01 ） ; applied antibiotic in reason was key（ P 〈 0.05）, there were singficant difference in GBS patients with ventilator or without（ P 〈 0.05）. Conclusion ： VAP of GBS patients accidents attack rate were relative to mang kinds of factor such as age of patients, time of ventilator and applied antibiotic, their moritality of GBS patients with VAP were more than to those without VAP.