口腔黏膜下纤维性变癌变危险因素的Logistic回归分析

Logistic regression analysis for the risk factors of malignant transformation of oral submucous fibrosis

目的探讨引起口腔黏膜下纤维性变癌变的危险因素,为自我预防和临床治疗提供理论依据。方法对病例组42例口腔黏膜下纤维性变癌变患者和对照组40例口腔黏膜下纤维性变未癌变者进行单因素、多因素Logistic回归分析,研究口腔黏膜下纤维性变癌变与14个相关因素之间的数量关系。结果Logistic回归结果提示,引入回归方程的4个因素为年龄、嚼槟榔持续时间、吸烟持续时间及合并白斑或扁平苔藓。结论年龄、嚼槟榔持续时间、吸烟持续时间以及合并白斑或扁平苔藓是口腔黏膜下纤维性变癌变的危险因素。

[Objective] To study the risk factors of malignant transformation of oral submucous fibrosis so as to supply the evidence for treatment and self-prevention. [Method] A case-control study was performed between 42 patients with malignant transformation of oral submucous fibrosis and 40 patients without malignant transformation of oral submucous fibrosis. The numeral relationship between the 14 interrelated factors and malignant transformation of oral submucous fibrosis was studied by the univariate and multivariate logistic regression analysis. [Results] Logistic regression analysis indicated that the four factors of age, duration of areca nut chewing, duration of smoking, and accompanied with oral leukoplakia or oral lichen planus entered the logistic regression equation. [ Conclusion ] This study identified that age, duration of areca nut chewing, duration of smoking, and accompanied with oral leukoplakia or oral lichen planus may be the risk factors in the cause of malignant transformation of oral submucous fibrosis.