奥美拉唑中间体的合成

The synthesis of the intermediate of omeprazole

目的:改进奥美拉唑中间体2-硝基-4-甲氧基-氨基苯的合成方法。方法:以扑热息痛为原料,经甲基化、硝化、还原等反应路线合成。结果:合成得到2-硝基-4-甲氧基-氨基苯,收率在70%左右。结论:该合成路线具有原料易得,反应条件温和等优点,并优化了原反应条件,提高了产率,适合工业化生产。

Objective： To improve the synthesis method of the intermediate of Omeprazole,2-nitro-4- methoxyl- aminobenzene.Methods： 2-nitro-4-methoxyl-aminobenzene was obtained by the process of methylation, nitration, reduction,etc. using paracetamol as material.Results： 2-nitro-4-methoxyl-aminobenzene was synthetized with the yield of about 70%. Conlusion： The synthesis method is improved, has a more high yield and can be used for industry.