急性脊髓损伤患者外周血淋巴细胞细胞间黏附分子-1的表达及其临床意义

The expression and clinical significance of ICAM-1 on leukocytes in the patients with acute spinal cord injuries

目的探讨急性脊髓损伤(spinal cord injury,SCI)患者外周血淋巴细胞细胞间粘附分子-1(intercellular adhe-sion molecular-1,ICAM-1)的表达及其临床意义。方法应用免疫荧光标记流式细胞仪检测15例急性SCI患者外周血淋巴细胞ICAM-1的表达,并与正常人群进行比较。结果急性SCI患者ICAM-1值显著高于正常人群(P<0.01)。结论急性SCI时患者外周血淋巴细胞ICAM-1表达明显升高,ICAM-1可能参与了急性SCI患者的免疫应答及脊髓损害过程,提示ICAM-1可能作为一个SCI预后判断的标志。

Objective To investigate the expression of ICAM-1 on lymphocytes in the patients with acute spinal cord injuties（SCI）. Methods The ICAM-1 on lymphocytes was determined by iminunofluorescence labelling and flow cytometry in 15 cases of acute spinal cord injuries. The data were compared with those in the healthy donors. Results It was found that the ICAM-1 was significantly higher （ P 〈0.01 ） in the SCI patients than those in the controls. Conclusion The expression of ICAM-1 on lymphocytes increased significantly in the patients with SCI, which indicated that ICAM-1 may play an active role in the immune response and in spinal cord injuries, it may be useful for prognostic marker for acute SCI.