男性2型糖尿病患者血浆性激素水平对胰岛素敏感性的影响

Effect of serum sex hormone levels on insulin sensitivity in men with type 2 diabetes

目的:探讨男性2型糖尿病患者血浆性激素对胰岛素敏感性的影响。方法:对37例男性2型糖尿病患者测定血清空腹血糖、空腹胰岛素水平,计算胰岛素敏感指数[ISI=In(FPG×FINS)-1],同时测定血清睾酮(T)、雌二醇(E2)水平,并计算E2/T,分析血清性激素与胰岛素敏感指数的相关性,34例非糖尿病人作为对照组。结果:血浆睾酮水平与胰岛素敏感性呈正相关(r=0.264,P<0.05)。结论:2型糖尿病患者低血浆性激素水平促进胰岛素抵抗的发生。

Objective： To examine the relationship between serum testosterone levels and insulin sensitivity in men. Methods ：A total of 37 men with type 2 diabetes were determined fasting plasma glucose （FPG） ,fasting insulin（FINS）. Insulin sensitivity was calculated by ISI = In（FPG× FINS）^-1. The serum testosterone and estradiol was assayed and calculated E2/T. Results ：Serum testosterone levels positive correlated with ISI （ r = 0. 264, P〈 0.05 ）. Conclusion ： Low serum sex hormone levels in men with type 2 diabetes may promote insulin resistance in men.