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SIRT1去乙酰化酶在热量限制法中的作用机制 被引量:3

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摘要 在延缓衰老的研究中,热量限制是目前唯一经过科学实验证实有效的方法,研究显示长寿基因SIRT1去乙酰化酶在此过程中发挥了重要的作用。SIRT1通过将p53、FOXO3a和Ku70等蛋白去乙酰化而抑制细胞凋亡,通过作用于PGC-1α和PPAR-γ等蛋白来调节糖代谢和脂肪代谢。本文就热量限制法延缓衰老中SIRT1的作用机制进行了综述。
出处 《国外医学(老年医学分册)》 2007年第4期145-149,共5页 Foreign Medical Sciences(Geriatrics)
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参考文献34

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同被引文献35

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