甲磺酸帕珠沙星原料药的急性毒性作用研究

Research on Acute Toxicity of Pazufloxacin Mesilate's Raw Material

目的研究甲磺酸帕珠沙星原料药的急性毒性作用,指导临床安全用药。方法按照《化学药物急性毒性试验技术指导原则》中方法进行试验。结果甲磺酸帕珠沙星原料药小鼠一次性灌胃最小致死量(MLD)大于5000mg/kg,小鼠静脉注射半数致死量(LD50)为439.35mg/kg,95%可信限为399.99～482.58mg/kg。结论甲磺酸帕珠沙星毒性小,使用安全范围大。

Objective To study the acute toxicity of pazufloxacin mesilate＇s raw material. Methods According to the method in Guiding Principle of Chemical Medicine＇s Acute Toxicity, the test was performed. Results Mice were divided into two groups. One group were poured the raw material of pazufloxacin mesilate with forece into stomaches, the MLD was more than 5 000 mg/kg. The other group were given by vein injection, the LDs0 was 439. 35 mg/kg. And 95% confidence interval was 399.99-482. 58 mg/kg. Conclusion The toxicity of pazufloxacin mesilate is small. It is safe and can be applied widely.