摘要
目的研究淫羊藿总黄酮(TFE)对局灶性脑缺血大鼠的保护作用。方法建立大鼠大脑中动脉阻塞模型(MCAO),以金纳多(含银杏内酯)为阳性对照组,观察TFE对脑缺血大鼠神经行为、脑含水量、脑梗塞面积、脑生化指标和脑组织病理变化的影响。结果TFE可改善MCAO大鼠神经行为,降低脑含水量,减少脑梗塞面积,升高ATP酶、超氧化物歧化酶(SOD)水平,降低丙二醛(MDA)水平,改善脑组织神经细胞缺血后病理改变。结论TFE对脑缺血大鼠有保护作用,其机制可能与改善能量代谢和抗氧化有关。
Objective To study the protective effects of total flavones of Herba Epimedii （TFE） on focal cerebral ischemia of rats. Methods Rat model of middle cerebral artery occlusion was established. With Jinnaduo as a positive control drug, the effect of TFE on the neurological behavior of cerebral ischemia rat, the cerebral water volume, the cerebral infarction area, the cerebral biochemistry and the pathologic change of brain were evaluated. Results TFE improved rats neurological behavior, decreased the cerebral water volume, reduced cerebral infarction area, increased ATPase and SOD activity, decreased MDA content, and also improved the pathological changes of ischemic brain. Conclusion TFE have the protective effect on cerebral ischemia in rats, its mechanism may be concerned about improving energy metabolism and anti- oxidation.
出处
《中药新药与临床药理》
CAS
CSCD
2007年第4期266-269,共4页
Traditional Chinese Drug Research and Clinical Pharmacology
关键词
淫羊藿总黄酮
局灶性脑缺血
保护作用
大鼠
Total Flavones of Herba Epimedii
Focal Cerebral Ischemia
Protective effect Rats
