青紫蓝兔体内Ghrelin的免疫组化定位

Immunohistochemical Localization of Ghrelin-containing Cells in the Chinchilla Rabbit

采用免疫组织化学方法研究了Ghrelin在青紫蓝兔(Oryctolagus cuniculus)体内的分布定位。结果显示,Ghrelin免疫阳性细胞分布于下丘脑、大脑皮质、延髓、脊髓、胃、小肠和大肠。下丘脑内的阳性神经元胞体主要分布于弓状核、室旁核、腹内侧核、背内侧核和下丘脑外侧区。胃肠道内的Ghrelin免疫阳性细胞存在两种类型,即"闭合型"细胞和"开放型"细胞。实验结果表明,兔体内Ghrelin的分布与人和其他动物的分布基本相似,但也存在一些差异。

Localization of ghrelin-containing cells in the Chinchilla Rabbit （Oryctolagus cuniculus ） was studied by immunohistochemistry. Ghrelon-containing cells were found to exist in the cerebral cortex, hypothalamus, thalamus, medulla obiongata, spinal cord, stomach, small and large intestines. In the hypothalamus, ghrehn-containing cells were identified in the arcuate, periventricular, dorsomedial and ventromedial hypothalamic nuclei, and lateral hypothalamic area. There were two kinds of ghrelin-containing cells, open- and dosed-type cells, in the gastrointestinal tracts. These results are similar to those obtained in human and other animals,indicating the conservation of ghrelin in phylogeny.