摘要
背景与目的:少突胶质细胞瘤是胶质瘤中的一种独立类型,近年来的研究显示少突胶质细胞瘤存在着不同于其它胶质瘤类型的分子遗传学改变。其中最显著的就是在大多数少突胶质细胞瘤中出现染色质1p和19q的缺失。同时还发现,有染色质1p及19q缺失病例,对化疗药物敏感性增强,生存期延长,反之预后差。本研究旨在研究胶质细胞瘤染色体1P杂合性缺失的特点。方法:本文使用荧光原位杂交(FISH)技术检测了我院脑外科手术的7例少突胶质细胞瘤及7例其他颅内肿瘤病例的染色体1p。结果:7例少突胶质细胞瘤中4例有1p杂合性缺失,而其他颅内胶质瘤病例中仅有2例出现1p杂合性的缺失。另外1p杂合性缺失的4例病变均为单侧,3例为颞叶,1例为额叶;肿瘤级别上3例为少突胶质细胞瘤(WHOⅡ级),1例为间变性少突胶质细胞瘤(WHOⅢ级)。结论:本研究提示1p杂合性缺失的发生率在少突胶质细胞瘤(4/7)比其它类型胶质瘤(2/7)为高。
BACKGROUND ＆ OBJECTIVE： Ohgodendroglioma is a distinct type among glioma, which shows differences in molecular compositions. Loss of Heterozygosity（LOH） on chromosome lp and 19q is the most common molecular alteration in ohgodendroglioma. It is believed to associate with positive chemosensitivity and favorable prognosis. M]ETHODS： Fluorescence in situ hybridization （FISH） was performed to investigative LOH on chromosome lp and 19q in 7 cases with oligodendroglioma and 7 cases with other types of glioma whom were treated in the department of neurosurgery, PLA General Hospital. RESULTS： LOH in chromosome in lp was detected in 4 oligodendrogliomas（57.1%）, while in only 2 cases of other types of glioma（28.5%）. CONCLUSIONS： Our results suggest the lp LOH is more frequntly occur in oligodendroglioma tham other type gliomas.
出处
《中国神经肿瘤杂志》
2007年第2期103-107,共5页
Chinese Journal of Neuro-Oncology
关键词
脑肿瘤少突胶质细胞瘤
杂合子
免疫荧光原位杂交
Oligodendrogliomas
LOH on chromosomes
fluorescence in situ hybridization （FISH）
