大剂量水剂青霉素治疗早期血清固定梅毒37例

37 Samples of Patients with Early Serofast Syphilis Treated by the Large Dose Aqueous Penicillin

目的观察大剂量水剂青霉素治疗早期血清固定梅毒的临床疗效与安全性。方法选择血清固定梅毒患者37例,给予大剂量水剂青霉素静脉滴注,2 400万U.d-1(每次400万U,q4 h),连续14 d;然后给予苄星青霉素,每周240万U肌内注射,共3次。结果治疗后3个月血清RPR试验滴度下降2个以上稀释度的比例为48.6%,6个月时为78.4%,9个月时为94.6%,12个月时RPR试验转阴率达83.8%。治疗过程中未出现明显不良反应。结论大剂量水剂青霉素治疗早期血清固定梅毒安全、有效。

Objective To evaluate the efficacy and safety of large close aqueous penicillin in the treatment of early serofast syphilis. Methods 37 patients with serofast syphilis were selected and iv drop with the large close of aqueous penicillin 2400 pan U · d^-1 （400 panU per q4 h） for 14 consecutive days, then im with benzathine penicillin 240 panU,weekly for 3 times. Results In each stage of follow-up, the RPR test titer descended more than 2 titers was 48.6% for 3 months of treatment, 78.4% for 6 months and 94.6% for 9 months, ,the negative turning rate was 83.8% at 12 months. No side effects were shown during the whole treatment. Conclusion Large close of aqueous penicillin is an effective and safety treatment for patients with early serofast syphilis.