摘要
目的制备GM-l PLGA微球,考察其一般性质和体外释药特性。方法应用W/O/W乳化溶剂干燥法制备GM-l PLGA微球,测定微球粒径、载药量、包封率和体外释药曲线。结果微球形态规则,粒径约为(18±8)μm,载药量约为4.9%,包封率约为61%,微球体外释药规律符合Higuichi方程:Q=0.153t1/2+0.037 05(r=0.995)。结论GM-l PLGA微球的制备工艺良好,体外释药呈明显的缓释作用。
Objective To prepare GM-1 PLGA microspheres and investigate their general properties and in vitro drug release characteristics. Methods The GM-1 PLGA microspheres were prepared by W/O/W emulsion-solvent evaporation technique. The size of particles, the amount of drug loading, efficiency of encapsulation and in vitro release curve were measured. Results The shape of optimized microshperes is normal, diameter of particles were all about ( 18 ± 8 )μm, the amount of drug loading was about 4.9% and efficiency of encapsulation was about 61%. The in vitro release profile was figured by Higuichi equation: Q = 0. 153t^(1/2) + 0. 037 05 ( r = 0. 995 ). Conclusion The preparation technology of GM-1 PLGA microspheres is good, which has significant sustained release characteristics.
出处
《医药导报》
CAS
2007年第8期924-926,共3页
Herald of Medicine