nm23-H1、cerbB-2在食管癌的表达及其与预后的关系

THE RELATIONAL OF NM23-H1 AND CERBB-2 EXPRESSION WITH ESOPHAGUS CARCINOMA PROGNOSIS

目的了解转移抑制基因(nm23-H1)和原癌基因(cerbB-2)在食管鳞癌组织中的表达及其与肿瘤临床、病理各指标间的关系。方法用免疫组化的方法分析上述基因在91例食管癌(鳞癌84例,腺癌3例,未分化癌4例)的表达。结果转移抑制基因nm23-H1和原癌基因CerbB-2染色均定位于细胞浆,两者均与淋巴结转移、预后情况呈显著相关性。在无淋巴结转移组,CerbB-2蛋白表达和预后呈显著负相关。结论nm23-H1高表达或CerbB-2低表达者,淋巴转移率低,术后生存率高,预后较好。CerbB-2可作为一个独立的预后指标,无论有无淋巴结转移者,CerbB-2蛋白高表达预后情况均差。

Objective To investigate the correlation of clinical Prognosis and expression of nm23 - H1 and cerbB -2 with esophagus carcinoma. Methods 91 cases of esophageal carcinoma, including 84 cases of squamous carcinoma, 3 cases of adenocarcinoma and 4 cases of undifferentiated small cell carcinoma were studied by immunohistochemistry method. The results showed low rate of lymph node metastasis and high long term survival rate were presented in the group with high expression of nm23 - H1 or low espression of CerbB - 2. In negative lymph node metastasis group, the expression of cerbB -2 was related to prognosis negatively. Conclusion CerbB -2 May play independent prognosis target rule.