三维适形放射治疗宫颈癌30例临床观察

CLINICAL OBSENATION ON THE TREATMENT OF CERVICAL CARCINOMA WITH THREE-DIMENSIONAL CONFORMAL RADIOTHERAPY

目的探讨三维适形放射治疗法治疗宫颈癌的临床效果。方法将30例中晚期宫颈癌患者,随机分为治疗组和对照组,治疗组15例为三维适形治疗,对照组患者15例为腔内后装放射治疗。结果治疗组近期总有效率96.7%,对照组93.3%,两组比较差异无统计学意义。直肠放射性近期反应发生率治疗组为20%,对照组为66.7%;膀胱放射性近期反应发生率治疗组为13.3%,对照组为53.3%,治疗组和对照组比较差异有统计学意义。直肠放射性远期并发症发生率治疗组为13.3%,对照组为53.3%;放射性膀胱炎的发生率治疗组为6.67%,对照组为46.67%;治疗组和对照组比较差异有统计学意义。结论三维适形放射治疗宫颈癌并发症少、副反应小,治疗时间短,肿瘤的局部控制率提高,同时也缩短了总的治疗时间。

Objective To explore the clinical effect of the treatment of cervical carcinoma with three - bimensional conformal radiotherapy（3D- CRT） and compare to that with traditional intracavitary radiotherapy. Methods 30 cases of medium to late stage cercical carcinoma were divided into the treatment group and the control group randomly from March 2004 to March 2006.15 cases were treated with a combination of external irradiation wirh 3D - CRT,the other 15 cases with the combination of external irradiation with intracavitary radiation therapy. Results The effective rates of the treatment group and the control group were 96.7 % and 93 % respectively, with no significant differenceThe rates of short - term radiation reaction of rectum of the treatment group and the control group were 20% and 66.7% respectively, and the rates of short- term radia- tion reaction of bladder were 13.3% and 53.3% respectively, with significant difference between the two groups. The rates of long- term radiation reaction of rectum were 13.3% and 53.3% respectively, and the rates of radia - tion bladderifis were 6.67% and 46.67% respectively and showed significant difference. Conclusion The therapeutic effect of 3 D - CRT was similar to that of traditional external radiotherapy in the treatment of cervical carcinoma , but the former had a lower rate of complications and shortened treatment term.