成人血和尿铅浓度和同位素比值的关系及地域影响研究

Relation and Area Effect Studies of Lead Concentration and Lead Isotope Ratios in Adult Blood and Urine

目的研究成人血和尿中铅浓度、血、尿铅同位素比值之间的关系以及是否存在地域影响。方法用ICP-MS测定全血和尿液消化液中铅浓度及铅同位素比值,并用CAIS方法校正基体效应。结果成人血铅和尿铅的平均浓度不同,且差异有统计学意义;血铅和尿铅同位素比值的差异也有统计学意义;成人尿铅的同位素比值还随地区不同而变化,差异有统计学意义。结论尿铅不能代替血铅作为生物标志物反映体内铅负荷以及铅同位素比值;处于不同地域的人不仅血铅同位素比值不同,尿铅同位素比值亦不同;人体有可能对铅同位素产生“分馏”作用。

Objective To study the relationships of lead concentrations and lead isotope ratios between adult blood and urine, and the area effects of lead isotope ratios. Method Lead concentrations and isotope ratios were determined by ICP-MS, and were corrected by CAIS for matrix effect. Results The lead concentrations in adult blood and urine may be significant differences in the same city, the lead isotope ratios in adult blood and urine also may be significant differences in the same city; the lead isotope ratios in adult blood in Beijing and Chengdu may be significant differences. Conehtsion The lead in urine could not reflect the lead concentration and lead isotope ratios in human body as a biomarker; the lead isotope ratio values in adult urine might depend on area difference; the human body may be able to fractionate the lead isotopes.