糖尿病肾病患者血红蛋白浓度的研究

Study on Hemoglobin Concentration of Patients with Diabetic Nephropathy

目的探讨糖尿病肾病患者血红蛋白浓度与终末期肾病之间的关系,及血红蛋白浓度与其它临床指标之间的关系。方法回顾性分析203例糖尿病肾病患者的临床资料和实验室资料;根据血红蛋白浓度的不同将研究对象分为三组,A组Hb<100g/L,B组100g/L≤Hb<120g/L,C组Hb≥120g/L。结果三组血肌酐的值分别为(432.74±37.60)μmol/L、(220.32±23.88)μmol/L、(111.67±10.73)μmol/L,各组间差异具有统计学意义(P<0.05)。血红蛋白浓度越低血肌酐值越高,到达终末期肾病患者的比例越高。各组收缩压、尿素氮、尿酸的组间差异也具有统计学意义(P均<0.05)。结论低血红蛋白浓度是终末期肾病的危险因素;血红蛋白浓度对其它一些临床指标的数值有一定的影响。

Objective To study the relationship between hemoglobin concentration and end-stage renal disease in the patients with diabetic nephropathy. Methods Clinical and laboratory data from 203 patients were retrospectively analyzed. Original data were divided into three groups according to hemoglobin concentration, A group with Hb〈100 g/L, B group with 100 g/L ≤Hb〈 120 g/L, C group with Hb ≥ 120 g/L. Results The serum levels of creatinine of A, B and C groups showed significant differences （432.74±37.60） μmol/L, （ 220.32±23.88 ） μmol/L, （ 111.67± 10.73） μmol/L, respectively （P〈0.05）. The lower hemoglobin concentration, the higher was the serum level of creatinine. The interclass differences of some other clinical index such as systolic pressure, blood urea nitrogen and blood uric acid also showed statistical significance （P〈0.05）. Conclusion The low hemoglobin concentration is the risk factor of end-stage renal disease. The hemoglobin concentration can influence some other clinical index.