儿童上消化道出血与幽门螺杆菌感染的关系

The Relationship between Upper Gastrointestinal Bleeding and Helicobacter pylori Infection in Children

目的研究儿童上消化道出血与幽门螺杆菌(Helicobacter pylori,Hp)感染之间的关系。方法对98例上消化道出血患儿组和65例非上消化道出血患儿组同时用13C-尿素呼气试验(13C-UBT)和采用ELISA法测定血清Hp抗体来判断Hp感染情况,所有患儿均行电子胃镜检查。结果上消化道出血患儿组和非上消化道出血患儿组的Hp阳性率分别为59.18%、18.46%,两组比较差异有统计学意义(P<0.001)。结论儿童上消化道出血与幽门螺杆菌感染有密切关系。

Objective To explore the relationship between upper gastrointestinal bleeding and Helicobacter pylori infection in children. Methods Gastroscopy was used to examine upper gastrointestinal bleeding. 98 children with upper gastrointestinal bleeding and 65 children without upper gastrointestinal bleeding were included in this study. Both 13C-UBT and ELISA method for the testing of serum anti-H, pylori antibody were used to test for the infection. Results The positive rate of H. pylori infection in the group with or without upper gastrointestinal bleeding was 59.18% and 18.46%, respectively. The difference was statistically significant between these two groups （P〈0.001）. Condusion The incidence of upper gastrointestinal bleeding is closely related to H. pylori infection in children.