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神经元胞体-树突的耦合对放电模式影响的仿真研究

A Simulation Study of Relationship between Coupling Effect of Soma-Dendrite and Firing Patterns
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摘要 应用神经元胞体-树突放电模型,在胞体与树突不同耦合作用的情况下,研究神经元放电模式的变化。设计三类刺激:胞体输入刺激(A)、树突输入刺激(B)、对胞体和树突同时输入刺激(A+B),分别研究在不同耦合电导gc时神经元的放电模式,通过在刺激(A+B)与刺激A和B时放电模式比较,研究输入刺激和放电模式的非线性关系。结果表明:(1)当耦合电导gc=0mS/cm2时,胞体和树突为相互独立的两个房室;(2)当耦合电导gc→∞时,胞体和树突合并为一个房室。在以上两类情况下,对两个房室输入(A+B)时胞体的放电与分别A和B叠加时的放电呈线性关系。(3)当耦合电导0<gc<∞时,胞体的放电模式随耦合电导的变化呈现节律性放电→爆发性放电→节律性放电的复杂变化。在0<gc<∞mS/cm2时,输入(A+B)时胞体的放电模式与输入呈现非线性关系。综上,胞体-树突之间的耦合对神经元放电模式具有影响作用。 The aim of this study is to investigate how firing patterns of hippocampus neuron change with coupling effect between soma and dendrite via simulation of single neuron firings by soma-dendrite model. The model was given stimulations to soma only (A), to dendrite only (B), to both soma and dendrite (A + B). Results showed: (1) When gc = 0mS/cm^2, soma and dendrite were two independent unit; (2) When gc→∞, the model was reduced to single compartment model. Under these two extremes, firing patterns of both compartments under (A + B) was linear to that of the sum of A and B. (3) When gc was 0 〈 gc 〈 ∞ mS/cm^2, firing patterns of both compartments changed in a complicated manner with gc from repetitive firing to bursting and again repetitive firing. Firing patterns of both compartments for gc in this range under ( A + B) was nonlinear to that of the sum of A and B.
作者 刘婷 田心
出处 《中国生物医学工程学报》 CAS CSCD 北大核心 2007年第4期481-486,492,共7页 Chinese Journal of Biomedical Engineering
基金 国家自然科学基金资助项目(60474074)。
关键词 海马 神经元 胞体-树突两房室模型 耦合 放电模式 hippocampus neuron soma-dendrite model coupling firing patterns
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参考文献15

  • 1Eichenbaum H.Hippocampus:Cognitive processes and neural representations that underlie declarative memory[J].Neuron,2004,44:109-120.
  • 2Fortin N,Agster K,Eichenbaum H.Critical role of the hippocampus in memory for sequence of events[J].Nature Neuroseience,2002,5(5):458-462.
  • 3Meeter M.Long-term memory disorders:measurement and modeling[D].Amsterdam:Amsterdam University,2003.
  • 4Burgess N.The hippocampus,space,and viewpoints in episodic memory[J].The Quarterly Journal of Experimental Psychology,2002,55A(4):1057-1080.
  • 5Hodgkin AL,Huxley AF.A quantitative description of membrane current and its application to conduction and excitation in nerve[J].Physiol,1951,117:500-544.
  • 6Chay TR,Fan YS,Lee YS,Bursting,spiking,chaos,fractals and universality in biological rhythms[J].Int J Bifurcation and Chaos,1995,5:595-635.
  • 7Traub RD,Wong R,Miles R,et al.A model of a CA3 hippocampal pyramidal neuron incorporating voltage-clam data on intrinsic conductances[J].J Neurophysiol,1991,66:635-650.
  • 8Pinsky P,Rinzel J.Intrinsic and network rhythmogenesis in a reduced Traub model for CA3 neurons[J].J Comput Neurosci,1994,1:39-60.
  • 9Feng Jianfeng,Li Guibin.Impact of geometrical structures on the output of neuronal models:A theoretical and numerical analysis[J].Neural Comput,2002,14(3):621-640.
  • 10Kepecs A,Wang Xiaojing.Analysis of complex bursting in cortical pyramidal neuron models[J].Neurocomputing,2000,32-33:181-187.

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