国内文献有关针刺对视神经萎缩疗效的循证医学评价

Evidence-based medicine analysis of academic theses in China of acupuncture therapy in optic atrophy treatment

目的评价针刺参与视神经萎缩治疗研究的质量及其有效性。方法通过检索中国期刊网(CNKI)、中国生物医学文献光盘数据库(CBMdisc)、万方数据库、中文科技期刊全文数据库(VIP)的国内期刊,对已发表的相关文献进行循证医学评价。结果共获得3个随机对照试验(RCT)和4个临床对照试验(CCT)的资料提取和分析。结论针刺加药物治疗与单纯药物治疗相比,对视神经萎缩患者视功能的改善效果更佳(P<0.0001),但因纳入研究数量少,且方法学上存在不同程度的缺陷,故其证据强度较低,需要更多严格设计的大样本和多中心的研究以提高针刺疗效的证据强度。

OBJECTIVE To estimate the quality and efficacy of the academic theses of acupuncture therapy in optic atrophy treatment. METHODS We searched CNKI, CBM disc, Wanfang（ 万方 ） database and VIP database magazines published in China, and analyzed them according to the criteria of evidence - based medicine（EBM）. RESULTS A total of 7 theses written in Chinese were retrieved, quantitative meta - analysis was done for 3 studies of RCTs and 4 CCTs. CONCLUSIONS The existing evidence supports the combination therapy of acupuncture and drugs stronger than the therapy in which drugs were used only and the difference was significant（ P 〈 0.0001） ,but only 7 the- ses were retrieved and all of them have methodological short comings, the evidence is not convincing. There is an urgent need of well - planed, large - scale and multiple - center studies to assess the effectiveness of acupuncture under real life conditions.