双重病因对新生儿高胆红素血症发生率影响探讨

A study of the effect of dual causa morbi on the morbidity of hyperbilirubinemia among neonates

目的:探讨存在葡萄糖6磷酸脱氢酶(G6PD)缺乏和新生儿溶血病(HDN)双重病因对新生儿高胆红素血症发生率的影响。方法:按检验操作规程对足月健康新生儿脐血进行G6PD和HDN血型血清学检验,对存在G6PD缺乏和HDN病因的新生儿调查其高胆红素血症发生率。结果:①G6PD缺乏组、HDN病因组、G6PD缺乏与HDN双重病因组的患儿高胆红素血症发生率均极显著高于正常对照组的新生儿(P<0.01);②存在G6PD缺乏和HDN双重病因的患儿高胆红素血症发生率极显著高于G6PD缺乏组和HDN病因组的患儿(P<0.01)。结论:存在G6PD缺乏和HDN双重病因的患儿红细胞溶血破坏的几率增高,其发生高胆红素血症的可能性更大。

Objective： To study the effect of glucose -6 phosphate dehydrogenate （G6PD） deficiency and hemolytic disease of the newborn （HDN） on the morbidity of hypelbilirubinemia among neonates. Methods： According to clinic detection rules, G6PD and HDN with umbilical blood of the mature healthy neonates were determined to study the morbidity of hyperbilirubinemia of the neonates with dual G6PD deficiency and HDN. Results ： ①Comparing to control group, the morbidity of hyperbilirubinemia was extremely higher in the G6PD deficiency, HDN group or dual G6PD deficiency and HDN group （P 〈0. 01） . ②Comparing to G6PD deficiency group or HDN group, the morbidity was extremely higher in dual G6PD deficiency and HDN group （P 〈0. 01 ） . Conclusion： In the dual G6PD deficiency and HDN patient - infants, the ratio of the wrecked erythrocyte is higher and the possibility of developing hyperbilirubinemia is much more.