腈菌唑毒性研究

Toxicity Study on Myclobutanil

利用霍恩氏法测定９９％腈菌唑原药对大小鼠的急性经口ＬＤ５０值分别为：大鼠雄性１４７０毫克／公斤，雌性１０８０毫克／公斤；小鼠雄性１０８０毫克／公斤，雌性６８１毫克／公斤。经皮ＬＤ５０值雄雌均大于１００００毫克／公斤。２５％腈菌唑乳油对大小鼠ＬＤ５０值分别为：大鼠雄性４３００毫克／公斤，雌性５０１０毫克／公斤；小鼠雄性１７１０毫克／公斤，雌性２０００毫克／公斤，属低毒性农药，对眼有轻微刺激，对皮肤无刺激作用。在动物体内蓄积性极弱，Ａｍｅｓ试验。

Using Horn's ditermination method the toxicity of Myclobutonal was as follows:technical produrct ,acute oral LD 50 to rats male 1470 mg/kg and female 1080mg/kg,to mice,male 1080mg/kg and female 681mg/kg.Acute skin LD 50 to mine (male and female)was more than 10,000mg/kg,25% myclobutanil EC,acute oral LD 50 to rats ,male 4300mg/kg and female 5010mg/kg.This product was light irritating to eyes and no irritating to the skin and very light accumulation in tested animal body.Ames,micronucleus test and sperm deformation test showed the negative ,the product was classified in low toxicity pesticide.