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中风后抗轴突生长抑制因子DNA免疫促进脑缺血功能恢复

Effect of Prestroke DNA immunization against Neurite Growth Inhibitors on the Neurological Improvement Following Local Cerebral Ischemia
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摘要 目的探讨中风后抗轴突生长抑制因子DNA免疫对脑缺血神经功能康复的促进作用。方法通过永久性阻断大脑中动脉诱导左侧局部脑缺血后,经腓肠肌注射抗轴突生长抑制因子DNA疫苗免疫动物,每周一次、共6周;分别采用改良的神经病严重程度记分、被动逃避试验和悬臂迷宫试验来评价运动功能、认知行为和焦虑样情感的恢复。结果中风后接受抗轴突生长抑制因子DNA免疫,局部脑缺血后出现明显的运动功能恢复,但是认知行为和焦虑样情感障碍则没有明显改善。结论中风后抗轴突生长抑制因子DNA免疫可促进脑缺血后的运动功能恢复。 Obiective To conform the effect of prestroke DNA immuniztion against neurite growth inhibitors on the neurological improvement following permanent local cerebral ischemia. Methods Left local ischemia was permanently induced through the occlusion of the middle artery (MCAO) and the DAN immunization was carried out by intramuscular injection of pc DNA 3.1 ( + )-neurite growth inhlbitors Hpc DNA-NGIs) into the tibial muscle once a week for 6 weeks. The following program of the modified neurological severity score (mNSS) ,the passive avoidance task and the elevated plus maze task were respectively used to test the sensorimotor deficit, the cognitive behavior and the anxietic affecton behavior. -like a. Results Poststroke DNA immunization against neurite growth inhibitors led to increased sensorimotor recovery affective but no maked recovery of there was of achieved following local cerebral ischemia. Conclusions Prestroke DNA immunization with pcDNA-NGIs can enhance the neurological improvement following local cerebral ischemia.
出处 《西南军医》 2007年第4期2-4,共3页 Journal of Military Surgeon in Southwest China
基金 新加坡国家卫生部和新加坡健康研究基金资助
关键词 轴突生长抑制因子 DNA免疫 局部脑缺血 行为 neurite growth inhibitors DNA immunization focal cerebral ischemia behavior
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参考文献9

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