吲哚胺2,3-双加氧酶在结肠癌及其区域淋巴结中的表达与临床意义

The Expression and Clinical Significance of Indoleamine 2,3-dioxygenase in Colon Carcinomas and Its Regional Lymph Nodes

目的:探讨吲哚胺2,3-双加氧酶(IDO)在结肠癌及其区域淋巴结中的表达及其临床意义。方法:通过免疫组织化学染色法检测IDO在110例结肠癌原发灶、癌旁正常结肠上皮组织和区域淋巴结的表达,分析IDO表达与患者临床病理特征的关系。结果:IDO在结肠癌原发灶的表达水平与癌旁正常结肠上皮组织相似,其表达强度与患者的年龄、性别、TNM分期和5年生存率无关。在无转移的区域淋巴结中,IDO主要表达于树突样细胞,区域淋巴结强表达IDO患者的5年生存率较低(31.8%)。结论:在结肠癌细胞转移到区域淋巴结前,区域淋巴结中IDO的表达已使其处于免疫抑制状态,从而为肿瘤转移创造了有利条件,而肿瘤细胞是否表达IDO并不影响肿瘤的转移能力。

Objective： To explore the expression of indoleamine 2, 3-dioxygenease （IDO） in colon carcinomas and regional lymph nodes, as well as its clinical significance. Methods： Expression of 1DO was detected with immunochemistry in 110 cases of colon carcinoma including primary tumor, adjacent normal tissue, and regional lymph nodes. Meanwhile, the relationship between IDO expression and clinicopathological characteristics of the patients was analyzed. Results： IDO expression in primary tumors was similar to that in adjacent normal tissue. A relationship between IDO expression and gentler, age, TNM stage and 5-year survival was not observed. However, IDO was expressed in dendritic-like cells in regional lymph nodes withoul metastasis, and higher expression of IDO in these regional lymph nodes was correlated with poorer 5-year survival （31.8%）. Conclusion： Before metastasis IDO induces immunological suppression in regional lymph nodes, which may prepare the microenvironment for metastasis. However, the IDO expression in tumor cells themselves seems to be uninvolved in this process.