妊娠合并甲状腺功能亢进的诊治

Diagnosis and Treatment for Pregnancy Complicate with Hyperthyroidism

目的探讨妊娠合并甲亢的诊断和治疗。方法对妊娠合并甲亢孕妇给予丙基硫嘧啶口服治疗,密切监测甲状腺激素水平,根据监测结果调整药物剂量。结果21例规范治疗,甲亢控制较好孕妇妊娠顺利,母婴无并发症。3例治疗不规范,甲亢控制不佳者出现严重并发症。结论TPU是目前治疗甲亢首选药物,合理规范用药,密切监测甲状腺激素水平,根据激素水平调整药物剂量是保证母婴安全的关键。

Objective To explore the diagnosis and treatment of the hyperthyroidism in the pregnant women. Methods 24 cases of pregnant women with hyperthyroidism were treated by oral anti-thyroid drug propyhhiouracil （PTU）. During the period of therapy ,the level of the maternal thyroid function was measured strictly. According the maternal thyroid function, the amount of anti-thyroid drugs was adjusted. Results The hyperthyroidism was well controlled and the infant was healthy in 21 patients who received a standard anti-thyroid therapy. Three cases who received an unsatisfied therapy had serious complications. Conclusions PTU was the best choice for the pregnant women with hyperthyroidism. It was very important to improve maternal and infant healthy by evaluating the maternal thyroid function frequently and reversed the amount of drugs based on the levels of FT3 , FT4 and TSH.