期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

组蛋白赖氨酸甲基化在表观遗传调控中的作用 被引量：10

The roles of histone lysine methylation in epigenetic regulation
下载PDF
导出
摘要 组蛋白赖氨酸的甲基化在表观遗传调控中起着关键作用。组蛋白H3的K4、K9、K27、K36、K79和H4的K20均可被甲基化。组蛋白H3第9位赖氨酸的甲基化与基因的失活相关连;组蛋白H3第4位赖氨酸和第36位赖氨酸的甲基化与基因的激活相关连;组蛋白H3第27位赖氨酸的甲基化与同源盒基因沉默、X染色体失活、基因印记等基因沉默现象有关;组蛋白H3第79位赖氨酸的甲基化与防止基因失活和DNA修复有关。与此同时,组蛋白的去甲基化也受到更为广泛的关注。 Histone lysine methylation plays a key role in epigenetic regulation.There are five lysines within histone H3（K4, K9, K2.7, K36, K79）. Besides, one lysine within histone H4（K2.0） has been shown to be methylated by specific histone lysine methyltransferase. Methylation at H3-K9 is associated with transcriptional repression, while methylation at H3-K4 andH3-K36 is associated with transcriptional activation. The methylation of histone H3-K2.7 was proved to be linked to several silencing phenomena including homeotic-gene silencing, X inactivation and genomic imprinting. H3-K79 methylation plays a role in DNA repair and transcriptional activation, and the extent and biological significance of histone demethylation will surely attract great attention.
作者 杜婷婷 黄秋花
机构地区 上海交通大学附属瑞金医院
出处 《遗传》 CAS CSCD 北大核心 2007年第4期387-392,共6页 Hereditas（Beijing)
基金 国家自然科学基金项目(编号:30370334)资助~~
关键词 组蛋白赖氨酸甲基转移酶 组蛋白赖氨酸甲基化 组蛋白去甲基化 histone lysine methyltransferases histone lysine methylation histone demethylation
分类号 Q75 [生物学—分子生物学]
  • 相关文献

参考文献38

  • 1Strahl BD,Allis CD.The language of covalent histone modification.Nature,2000,403(6765):41-45.
  • 2Rea S,Eisenhaber F,OCarroll D,Strahl BD,Sun ZW,Schmid M,OpravilS,Mechtler K,Ponting CP,Allis CD,Jenuwein T.Regulation of chromatin structure by site specific histone H3 methyltransferases.Nature,2000,406(6796):593-599.
  • 3Gol IMG,Bestor TH.Histone modification and replacement in chromatin activation.Genes Dfez,2002,16(14):1739-1742.
  • 4Nakayama J,Rice JC,Strahl BD,Allis CD,Grewal SI.Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly.Science,2001,292(5514):110-113.
  • 5Schultz DC,Ayyanathan K,Negorev D.SETDBI:a novel KAP-1-associated histone H3,lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.Genes Dev,2002,16(8):919-932.
  • 6Derunes C,Briknarovak K,Geng L,Gessner CR,Hewitt K,Wu S,Huang S,Woods VI Jr,Ely KR.Characterization of the PR domain of RIZ1 histone methyltransferase.Biochem Biophys Res Commun,2005,333(3):925-934.
  • 7Guory I,Wu J,Fejer G,Seto E,Wright KL.PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing.Nat Immunol,2004,5(3):299-308.
  • 8Tachibana M,Ueda J,Fukuda M,Takeda N,Ohta T,Iwanari H,Sakihama T,Kodama T,Hamakubo T,Shinkai Y.Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9.Genes Dev,2005,19(7):815-826.
  • 9Tachibana M,Sugimoto K,Nozaki M,Ueda J,Ohta T,Ohli M,Fukuda M,Takeda N,Niida H,Kato H,Shinkai Y.G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis.Genes Dev,2002,16(14):1779-1791.
  • 10Vakoc CR,Mandat SA,Olenchock BA,Blobel GA.Histone H3 Lysine 9 methylation and HP1 are associated with transcription elongation through mammalian chromatin.Mol Cell,2005,19(3):381-391.

同被引文献198

引证文献10

二级引证文献24

遗传
2007年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部