肾病综合征患儿血IgG与尿蛋白变化的分析

The relationship between serum level of IgG and proteinuria in children with nephrotic syndrome

目的观察儿童原发性单纯性肾病综合征血免疫球蛋白G(IgG)与尿蛋白变化之间有无相关关系。方法运用医学统计学方法,分析46例初次发病且未经激素治疗的原发性单纯性肾病综合征患儿血IgG变化与尿蛋白定量的关系。结果血IgG与尿蛋白定量之间不存在线形回归关系,也无相关关系。结论部分肾病综合征患儿发病时即有血IgG水平降低,但分析显示血IgG水平与尿蛋白定量之间不存在线形回归关系,也无相关性,提示大量蛋白尿可能不是某些原发性单纯性肾病综合征患儿血IgG水平降低的主要原因。

Objective To investigate the relationship between serum IgG and proteinuria in children with nephrotic syndrome. Methods Biostatistics was used to study the relationship between the serum level of IgG and the quantitative changes of urine protein in 46 pediatric patients with simple primary nephrotic syndrome which had not been treated with steroid therapy. Results No linear regression, nor correlation was found between the serum IgG and the quantity of urine protein （ P 〉 0.05 ）. Conclusion Although lowered IgG level may be seen in some nephrotic children, the present investigation revealed no linear regression or correlation betweem serum IgG and proteinuria, suggesting that heavy proteinuria may not be the main cause of the lowering of serum IgG in children with nephrotic syndrome.