原发性肺淋巴瘤的综合治疗与预后分析(附12例报告)

Composite Treatment and Prognostic Analysis of Primary Pulmonary Lymphoma

目的探讨原发性肺淋巴瘤(PPL)的综合诊治方法、分析预后。方法回顾分析12例PPL的临床表现、影像学特点及诊治方法,总结治疗经验。10例临床病例均经过手术治疗和手术后病理证实。2例在术前经皮肺穿刺活检明确诊断。结果PPL占同期手术的肺恶性肿瘤的0.5%(12/2 239)。10例手术后病理诊断为非霍奇金淋巴瘤(B细胞型),其中2例在手术后3年内死亡;2例为霍奇金病,均在手术后8个月、17个月死亡。结论PPL在临床上较少见,术前诊断较为困难,确诊需要病理证实,治疗PPL应采用综合治疗方案,包括手术、放疗、化疗及生物治疗等。

Objective To explore the composite treatment and prognostic factors of primary pulmonary lymphoma. Methods The clinieopathological characteristics, the imaging feature and the experience in the composite treatment of 12 patients with primary lymphoma were analyzed retrospectively. Ten patients were surgically operated and pathologically confirmed, and two were pathologically confirmed by biopsy. Results Primary pulmonary lymphoma was found to account for aboui 0.5% in primary pulmonary car- cinoma during the same period （12/2 239）. Ten patients were confirmed as non-Hodgkin＇ s lymphoma （B-type） by pathology, and two of the ten died postoperatively within three yeats. The other two ones suffering from Hodgkin＇ s disease died respectively in eight and 17 months after operation. Conclusion Primary pulmonary lymphoma is clinically rare and short of typical clinicopathological characteristics, so its preoperatively exact diagnosis is difficult. The management of primary pulmonary lymphoma includes surgical management, postoperative radiotherapy and regular chemotherapy.