咪达唑仑联合丙泊酚在胃内镜检查中的应用价值

Applicative Value of Midazolam Combined with Propofol in Gastroscopy

目的比较咪达唑仑与丙泊酚联合应用与分别应用在胃镜检查中的镇静作用及对呼吸循环的影响。方法胃镜检查患者90例随机分为三组,每组30例。Ⅰ组静注咪达唑仑0.08 mg/kg,Ⅱ组静注丙泊酚2.5 mg/kg,Ⅲ组静注咪达唑仑0.05 mg/kg+丙泊酚1 mg/kg。观察术中镇静程度及记忆缺失、苏醒时间、HR、SBP、DBP和脉搏血氧饱和度(SpO2)的变化。结果Ⅱ组BP,SpO2下降比Ⅰ、Ⅲ两组显著(P<0.05)。Ⅱ、Ⅲ两组镇静程度和苏醒时间相仿且均优于Ⅰ组。结论咪达唑仑0.05 mg/kg+丙泊酚1 mg/kg辅助胃镜检查效果好且安全。

Objective To compare the effects of midazolam plus propofol on sedation and on respiration and circulation with other methods for gastroscopy. Methods Ninety patients due to undergo gastroscopy were averagely divided into three groups at random, i, e, Group A, Group B and Group C （n = 30 ）, The three groups were intravenously injected with midazolam （0.08 mg/kg） , propofol （2, 50 mg/kg）, and midazolam （0.05 mg/kg） plus propofol （ 1.00 mg/kg）, respectively. During the gastroscopy, observation was carried out on the changes in sedative depth, memory loss, revival time, heart rate （HR） , systolic blood pressure （ SBP）, diastolic blood pressure （DBP） and oxygen saturation of pulse （ SpO2 ）, Results The decrease in blood pressure （BP） and SpO2 was more significant in Group B than in Group A or Group C （ P 〈 0.05 ）, Furthermore, the sedative depth and the revival time were similar between Group B and Group C, but more satisfactory than that of Group A, Conclusion It is suggested that the application of midazolam （0.05 mg/kg） plus propofol （1.00 mg/kg） can achieve a good and safe outcome when subsidiarily applied to gastroscopy.