脉冲振荡法在慢性咳嗽临床应用中的探讨

Clinical application of impulse oscillometry method in chronic cough

目的观察本院门诊就诊的慢性咳嗽患者的肺通气功能及气道阻力变化情况。方法设立实验组和健康对照组,采用普通肺功能及脉冲振荡法检查,比较两组75%最大呼气流量(MEF75)、50%最大呼气流量(MEF50)、25%最大呼气流量(MEF25)以及脉冲振荡法之呼吸总阻抗(Z5)、总气道阻力(R5)、中心气道阻力(R20)及周边弹性阻力(X5)各项指标的数值变化。实验组行支气管扩张剂治疗14d,再观察上述指标。结果治疗前实验组同健康组比较,各项指标差异有统计学意义。实验组治疗前后比较,各项指标差异有统计学意义。治疗后实验组与对照组比较,各项指标差异无统计学意义。结论总气道阻力、小气道阻力及周边弹性阻力增加,大气道阻力未增加。支气管扩张剂治疗慢性咳嗽有效。

Objective To investigate the changs of the lung ventilation function and the small airway resistance of the out-patients suffering from chronic cough in our hospital. Methods The subjects were divided at random into experiment group and healthy control group. Common pulmonary functon test and impulse oscillometry method were adopted to examine FEV1, MEF75, MEF50, MEF25, Z5, R5, R20 and X5. The data in the two groups were compared. After 14 d＇s treatment of bronchodilator, the above parameters were examined again. Results There was statistical difference of each of the above parameters between the two groups before treatment, while the difference was significant before and after treatment. Each of the parameters in post-therapy group was higher markedly than that in healthy control group. Conclusion The total airway resistance, small airway resistance and peripheral flexibility resistance increase in chronic cough.