血清总胆汁酸在肝脏疾病诊治中的意义

Clinial significance of serum total bile acid detection in liver diseases

目的通过测定急、慢性病毒性肝炎、重型肝炎和肝硬化等不同肝病患者血清中总胆汁酸含量,探讨其在判定肝脏功能,指导临床治疗中的意义。方法采集健康对照组(n=82)、急性病毒性肝炎(n=45)、慢性乙型病毒性肝炎(n=156)、重型肝炎(n=41)、肝硬化患者(n=104)清晨空腹静脉血,用自动生化分析仪测定。结果急性病毒性肝炎组、慢性乙型病毒性肝炎组、重型肝炎组及肝硬化组血清TBA分别是健康对照组的42、15、66倍和9倍(P<0.05);慢性乙型肝炎患者随着病情的加重,血清TBA水平也显著升高。结论血清总胆汁酸含量的检测可了解肝细胞受损情况,可作为肝功能检测的辅助指标,对病毒性肝炎和肝硬化具有辅助诊断意义。

Objective To investigate the clinical value of serum total bile acid（TBA） in different types of hepatic diseases including acute viral hepatitis, chronic virus hepatitis, fulminant hepatitis and liver cirrhosis. Methods 82 healthy controls, 45 cases of acute viral hepatitis, 156 cases of chronic virus hepatitis B, 41 cases of fulminant hepatitis and 104 cases of cirrhosis cases were enrolled in our study. The venous blood were collected and serum TBA was detected with automated biochemistry analysis system. Results Serum TBA in acute viral hepatitis group, chronic virus hepatitis B group, fulminant hepatitis group and cirrhosis group was 42, 15, 66 and 9 times the value of healthy control group respectively. Serum TBA in chronic virus hepatitis B group increased with state of the illness. Conclusion Detection of serum TBA is helpful for assessment of liver function and diagnosis of viral hepatitis and cirrhosis.