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他汀类药物对急性冠状动脉综合征患者血清妊娠相关性血浆蛋白-A的影响 被引量：1

Effect of serum pregnancy-associated plasma-A level in patients with acute coronary syndrome treated with TATIN
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摘要 目的探讨应用他汀类药物后急性冠状动脉综合征(ACS)患者妊娠相关性血浆蛋白-A (PAPP-A)水平的变化。方法应用双抗夹心酶联免疫吸附法(EUSA)分别测定40例ACS应用他汀类药物前后、20例稳定型心绞痛(SA)及20例非冠心病患者血清PAPP-A水平。结果ACS患者血清PAPP-A浓度均明显高于SA组和非冠心病组患者。应用他汀类药物后ACS患者血清PAPP-A水平降低(均P<0.01)。结论PAPP-A浓度在ACS患者血中明显升高,为ACS易损斑块新的血清标志物。 Objective To investigate changes of the serum pregnancy-associated plasma protein-A （ PAPP- A ） level in the patients with acute coronary syndrome （ACS） after treatment with TATIN. Methods The serum PAPP-A was detected by ELISA in 40 ACS patients and 20 stable angina patients and 20 non-CAD patients. Results PAPP-A levels were significantly higher in patients with ACS than in patients with stable angina and non-CHD and were higher in patients with ACS after taking TATIN （ P 〈 0.01 ）. CondusIon PAPP-A levels are elevated in ACS and it is a new candidate marker of ACS which can reflect the instability of coronary atheroselerotie plaque.
作者 潘伟 韩玉龙 方长庚 张小勇 刘学路 马敏 章体玲
机构地区 广东省佛山市三水人民医院心血管内科 安徽医科大学第四临床学院心血管内科 云南省心血管病研究所冠心病基础研究室
出处 《中国医药》 2007年第9期524-526,共3页 China Medicine
关键词 急性冠状动脉综合征 妊娠相关性蛋白-A 易损斑块 Acute coronary syndrome Pregnancy-associated plasma protein-A Vulnerable plaque
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献6

  • 1Khosravi J,Diamandi A,Krishna RG,et al.Pregnancy associated plasma protein-A:ultrasensitive immunoassay and determination in coronary heart disease[].Journal of Clinical Microbiology.2002
  • 2Boldt HB,Overgaard MT,Lauresen LS,et al.Mutational analysis of the proteolytic domain of PAPP-A:Classification as a metzincin[].Biochemical Journal.2001
  • 3Overgaard MT,Boldt HB,Laursen LS,et al.Pregnancy-associated plasma protein-A2 (PAPP-A2),a novel insulin-like growth factor- binding protein-5 proteinase[].Biological Chemistry.2001
  • 4Lund J,Qin QP,Ilva T,et al.Circulatin gpregnancy-associated plasma protein-A??predicts outcome in patients with acute coronary syndrome but no troponin Ⅰ elevation[].Circulation.2003
  • 5Qin QP,,Laitinen P,,Eriksson S, et al.Release patterns of pregnancy associated protein A in patients with acute coronary syndromes[].Scandinavian Cardiovascular Journal.2002
  • 6Alberto Dominguez-Rodriguez Pedro Abreu-Gonzalez Mart&#xed,n Garcia-Gonzalez Julio Ferrer and Manuel Vargas.Circulating pregnancy-associated plasma protein A is not an early marker of acute myocardial infarction[].Clinical Biochemistry.2005

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  • 1[3]Sanders P,Morton JB,Kistter PM,et al.Reversal of artrial mechanical dysfunction after cardioversion of artrial fibrillation.Circulation,2003,108:1976-1984.
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  • 6[9]Montero I,Orbe J,Varo N,et al.C-reactive protein induces matrix metalloproteinase-1 and-10 in human endothelial cells:implications for clinical and subclinical atherosclerosis.J Am Coll Cardiol,2006,47:1369-1378.
  • 7[10]Gedikli O,Dogan A,Altuntas I,et al.Inflammatory makers according to types of artrial fibrillation.Int J Cardiol,2007,120:193-197.

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中国医药
2007年 第9期

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