胃肠道恶性肿瘤连续腹腔化疗临床研究

A clinical study of IPCT in mali nant tunor of gastrointestionl system.

目的研究胃肠道恶性肿瘤根治术后连续腹腔化疗较传统静脉全身化疗的优势。方法统计7年来胃肠道恶性肿瘤根治术后连续腹腔化疗(72例)和静脉全身化疗(70例)的治疗效果,比较两组患者生存率、复发率和不良反应的差异。结果连续腹腔化疗组1、2、3年生存率分别为90.3%、83.3%、77.8%,静脉化疗组1、2、3年生存率分别为80.0%、68.6%、58.6%。而不良反应(除腹痛、腹胀外)、复发率,连续腹腔化疗组均有明显优势。结论对于胃肠道恶性肿瘤根治术后辅助化疗,连续腹腔化疗优于静脉全身化疗。

Obective To investigate the benefit of continuous intraperitioneal chemotherapy （IPCT） compared to intravenous chemotherapy （IVCT） after curative operation for malignant diseases of gastrointestinal system. Methods To statistics the results of continuous IPCT after curative operation for 72 cases of advanced gastrointestinal cancer compared to the results os IVCT for 70 caes since seven years ago. The survival rate, recrudescence rate side effects were evaluated. Results The continuous IPCT group,with the 1,2 and 3 years survival fates 90.9% ,83.6% .78. 7% ,evidently higher than the IVCT group,80.0% ,68.8% .58.6% （ P 〈0.05 ）. The continuous IPCT group had fewer side effects （ except abdominal pain） and less recrudescence rate than the IVCT group. Conclusion Compared with IVCT,continuous IPCT is a better way for patients with gastrointestinal cancer after operation as adjuvant chemotherapy method.