甘利欣联合苦参素治疗慢性乙型病毒性肝炎肝纤维化指标的变化

The effects of Diammonium Glycyrrhizinate Association Kushenin on Index of Chronicity Viral Hepatitis type B Hepatic Fibrosis

目的观察联合应用甘利欣和苦参素治疗慢性乙型病毒性肝炎患者血清肝纤维化指标的变化。方法选择39例慢性乙型病毒性肝炎中度患者,随机分成:治疗组19例,联合应用甘利欣和苦参素治疗;甘利欣组20例,给予甘利欣治疗。分别于治疗前后一周内检测血清肝纤维化指标HA、LN、ⅣP。结果两组治疗前血清HA、LN、ⅣP均明显高于正常对照组(P<0.05)。两组患者治疗后的血清HA、LN、ⅣP水平较治疗前降低,治疗组血清HA、LN、ⅣP水平治疗前后存在统计学差异,且明显低于甘利欣组治疗后水平(P<0.05)。结论苦参素和甘利欣合用较与单纯应用甘利欣治疗慢性乙型肝炎可明显改善肝纤维化指标,说明苦参素有较强的抗肝纤维化作用。

Objective To study the effects of diammonium glycyrrhizinate association kushenin on index of chronicity viral hepatitis type B hepatic fibrosis. Methods Chose 39 cases whose chronicity viral hepatitis type B was midrange,radom subgroup, one group was 19 cases which used diammonium glycyrrhizinate association kushenin; diammonium glycyrrhizinate group was 20 cases which used diammonium glycyrrhizinate, all were detected index of serum hepatic fibrosis HA、LN、ⅣP before and after treatment. Results HA、LN、ⅣP of two group all lower than before treatment, diammonium glycyrrhizinate association kushenin group has statistics difference between before and after treatment, and lower more obviously than diammonium glycyrrhizinate group （P〈0.05）. Conclution Diammonium glycyrrhizinate association kushenin has more obviously effection on index of hepatic fibrosis,it indicated kushenin has anti hepatic fibrosis effection.