丹红注射液对大鼠心肌缺血再灌注损伤保护作用的实验研究

The Protective Effect of Danhong Injection on Experimental Myocardial Ischemic Reperfusion Injury in Rats

目的研究丹红注射液(DH)对心肌缺血再灌注损伤的保护作用。方法通过建立大鼠心肌缺血再灌注模型,研究不同剂量丹红注射液对心肌缺血再灌注损伤的保护作用。结果DH对大鼠缺血再灌注心肌梗塞范围的缩小作用呈剂量依赖性;减少缺血再灌注心肌细胞内肌酸激酶(CK)和乳酸脱氢酶(LDH)的释放;降低心肌缺血再灌注诱发的ST-T段的抬高。结论DH对大鼠心肌缺血再灌注损伤有明显保护作用。

Objective To study the protective effect of DH on experimental myocardial ischemic reperfusion induced injury. Methods Myocardial ischemic reperfusion injury model was used to study the protection of different dosage DH on myocardial ischemic reperfusion injury in rats. Results DH＇s effect on the reduction of the area of myocardial infarction induced by ischemic reperfusion was dose -dependent, it decreased the release of creative kinase（ CK） and lactate de-hydrogenase （ LDH ） from the injured myocardium and reduced elevation ST - T of electrocardiogram （ ECG ）. Conclusion DH has an obvious protective action on myocardial ischemic reperfused injury in rats.