4Baserga R, Hongo A, Rubini M,et al. The IGF-1 receptor in cell growth, transformation and apoptosis[J]. Biochimica et Biophysica Acta, 1997,1332 :105.
5Sambrook J, Frisch EF, Maniatis T. Molecular coloning a laboratory manual[M]. 2nd ed Gold Spring Harbor Laboratory Press, 1989.1.
6Sporn MB, Todaro GJ. Autocrine secretion and malignant transformation of cells[J]. N Engl J Med, 1980,303:878.
7Happerfield LC, Miles DW, Barnes DM. The localization of the insulin-like growth factor receptor 1 (IGFR-1) in benign and malignant breastt issue[J]. J Pathol, 1997,183(4):412.
8Guerra FK, Eijan AM, Puricelli L. Varying patterns of expressing of insulin-like growth factorl and Ⅱ and their receptors in murine mammary adenocarcinomas of different metastasizing ability[J]. Int J Cancer, 1996,65:812.
9Sell C, Dumenil G,Deveaud C, et al. Effeet of a null mutation of the insulin-like growth factor Ⅱ receptor gene on growth and transformation of mouse embryo fibroblasts[J]. Mol Cell Bio1,1994,14:3604.
10Kaledo M, Rutter WJ , Miller AD. Overexpession of human insulin-like growth factor 1 receptor promotes ligand-dependant neoplastic transformation[J]. Mol Cell Biol, 1990,10:464.
