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帕金森病发病机制的研究进展 被引量：8

Pathogenetic Progress of Parkinson′s Disease
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摘要 帕金森病是一种常见的中枢神经系统退行性疾病,引起帕金森病的发病机制至今尚未明确。本文就对帕金森病发病机制研究中的病理机制、环境因素、遗传因素、氧化应激、线粒体功能障碍、蛋白质的错误折叠和聚集等方面的研究进展进行综述。 Parkinson＇s disease （PD） is a common neurodegenerative disease in the central nervous system, of which the pathogenesis remains unclear to this day. This article reviews progresses of PD about its pathogenesis including pathomechanism, environmental factor, genetic facets, oxidative stress, mitochondrial dysfunction, misfolding and aggregation of protein and so on.
作者 陈燕 陆振虞
机构地区 上海交通大学基础医学院医学遗传学教研室
出处 《医学综述》 2007年第14期1078-1080,共3页 Medical Recapitulate
基金 上海市教委基金项目(03BZ03) 教育部博士点基金项目(20040266014) 校博士点基金项目(BXJ0304)
关键词 帕金森病 基因 病因学 Parkinson＇s disease Gene Etiology
分类号 R742.5 [医药卫生—神经病学与精神病学]
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参考文献16

  • 1Levy G,Tang MX,Louis ED,et al.The association of incident dementia with mortality in PD[J].Neurology,2002,59(11):1708-1713.
  • 2Dawson TM,Dawson VL.Molecular pathways of neurodegeneration in Parkinson's disease[J].Science,2003,302 (5646):819-822.
  • 3Pankratz N,Foroud T.Genetics of Parkinson Disease[J].NeuroRx,2004,1(2):235-242.
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二级参考文献17

  • 1Xu PY, Liang R, Jakovic J, et al. Association of homozygous 7048G7049 variant in the intron six of Nurrl gene with Parkinson's disease. Neurology, 2002,58(6) :881-884.
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  • 8Hyun DH, LeeM, Hattori N, etal. Effect of wild type or mutant parkin on oxidative damage nitric oxide antixidant defenses, and the proteoasome. J Biol Chem, 2002,277:28572-28577.
  • 9Dawson TM, Dawson VL. Molecular pathways of neurodegeneration in Parkinson's disease. Science, 2003,302(5646):819-822.
  • 10Pankratz N, Foroud T. Genetics of Parkinson' s disease. NeuroRx,2004,1:235-242.

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医学综述
2007年 第14期

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