摘要
用单克隆抗体PC10及抗Bcl-2蛋白对66例鼻咽癌进行回顾性免疫组化研究。结果,增殖细胞核抗原(PCNA)增殖指数(PI)分级在生存期长短两组之间差异显著(P<0.01),而在非角化鼻咽癌亚型之间无明显差异(P>0.05);Bcl-2蛋白在48/63例鼻咽癌中呈阳性表达,在不同生存期及不同亚型非角化鼻咽癌中的表达均无明显差异。结果表明:PCNA增殖指数可反映鼻咽癌的增殖状态,是较好的判断预后的指标,PI分级高者预后较差,低者预后较好。Bcl-2蛋白可做为鼻咽癌较好的肿瘤标记物,在鼻咽癌的发生上可能起重要作用。
An immunohistochemical study was performed retrospectively with monoclonal antibody PC10 and Anti Bcl 2 protein on 66 cases of NPC. In our study, there was significant difference in the grade of PCNA proliferating index (PI) (P<0.01), between two groups with different survival, but no significant difference between two subtypes of non keratinizing carcinoma(P>0.05).Bce 2 protein was expressed in 48/63 cases (76.19%) of NPC. The expression of Bcl 2 protein was not correlatted with above mentioned two factors (survival and subtype). The results suggest that PCNA PI may represent the proliferative state of NPC and have a prognostic significance. High grade of PCNA PI exhibites a poor prognosis in NPC cases and a contrary result in low grade cases. Bcl 2 protein may be a better tumor marker of NPC and may play an important role in tumorigenesis of NPC.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
1997年第1期22-26,共5页
Journal of China Medical University
基金
辽宁省科学技术资助
关键词
鼻咽肿瘤
增殖细胞核抗原
BCL-2
癌基因
预后
nasopharyngeal neoplasms
proliferating cell nuclear antigen(PCNA)
Bcl 2 oncoprotein
prognosis
immunohistochemical staining