双环醇治疗慢性乙型肝炎效果探讨

The efficacy of bicyclol in treating chronic hepatitis B

目的:评价双环醇治疗慢性乙型肝炎的疗效。方法:选取慢性乙型肝炎病人37例,给予双环醇25mg,3次/日,口服,共24周,停药12周,观察疗效。结果:应用双环醇治疗24周ALT明显下降,停药12周虽有所上升,但没有统计学意义。治疗24周和停药12周,ALT复常率分别为54.1%、35.1%。AST复常率分别为40.6%、34.4%。治疗结束和停药12周后,血清HBeAg阴转率分别为24.1%、34.5%,发生HBeAg血清转换1人。治疗24周末,HBV DNA阴转率为24.3%;停药12周,HBV DNA阴转率为27.0%。结论:双环醇对降低转氨酶有很好的疗效,且具有一定的抗病毒作用。

Objective： To assess efficacy of Bicyclol in treating the patients with hepatitis B. Methods ： There were 37 patients with hepatitis B received Bicyclol 25mg Tid for 24 weeks. Results ： At the 24th week of treatment and postdosing for 12 weeks, the proportion of returning to normality of ALT was 54.1% and 35.1% respectively, of AST was 40.6% and 34.4% respectively. The proportion of converting to negative of serum HBeAg was 24.1% and 34.5% at the end of treatment and at the 12th week after the end respectively. There was one subject had sero-conversion of HBeAg. 24.3% of the subjects＇ HBV DNA was negative when dosing for 24 weeks, and 12 weeks later, 27.0% of the subjects＇ HBV DNA was negative. Conclusion： The efficacy of bicyclol is satisfactory in decreasing the ALT level, and it has some effects in antivirus.