摘要
应用离体灌注的大鼠工作心脏模型，研究常温及低温缺血条件下不同预调方案的心肌保护作用。结果表明，无论在常温或低温缺血条件下，缺血预调均可促进缺血后心肌功能的恢复，诱导心肌保护作用。对常温缺血心肌单次5min缺血再灌注的预调方案产生最佳的保护作用，但在低温缺血心肌，两次5min缺血再灌注才可诱导最佳的保护作用。当最大的保护作用诱导后，进一步预调不再增强保护作用，缺血预调诱导的心肌保护作用具有饱和特性。
Using a modle of isolated working heart we investigated the protective effects of various preconditioning protocols on ischemic myocardium of hypothermia or normothermia. The preconditioning protocol of 5min× 1 time of ischemic period seems to have the most protective effect in normothermic series while 5min × 2 times of ischemic period appears the best to induce myocardium protection in hypothermic series. Conclusion: preconditioning offers the best protection to ischemic myocardium of either normothermic or hypothermic. The preconditioning protocol of most effective result varies with the myocardial tempereature during ischemic period.
出处
《上海第二医科大学学报》
CSCD
1997年第1期22-24,共3页
Acta Universitatis Medicinalis Secondae Shanghai
关键词
缺血预调
心肌缺血
心肌功能
ischemic preconditioning
myocardial protection
myocardial ischemia
myocardial injury
myocardial function
reperfusion
