麻醉剂量羟甲芬太尼对大鼠脑内单胺递质及其代谢物含量的影响

Effects of ohmefentanyl in anesthetic dose on the levels of monoa- mine transmitters and their metabolites in rat brain

麻醉剂量羟甲芬太尼对大鼠脑内单胺递质及其代谢物含量的影响金昔陆１唐琴梅金文桥周德和李桂芬池志强（中国科学院上海药物研究所，上海２０００３１）羟甲芬太尼（ｏｈｍｅｆｅｎｔａｎｙｌ，ＯＭＦ）是一种新的高选择性高亲和力μ阿片受体激动剂，在动物中能产生麻醉作...

Effects of ohmefentanyl in anesthetic dose on the levels of monoamine transmitters and their metabolites in rat brain were studied using the HPLC coupled with that OMF in anesthetic dose 4.0 μg·kg -1 increased the contents of 5-HT in striatum from 0.05±0.02 to 0.19±0.08μg·kg -1 wet tissue (P<0.01) and 5-HIAA levels in striatum,hippocampus and frontal cortex from 0.06±0.04,0.05±0.05, and 0.05±0.04 to 0.28±0.08,0.13±0.07, and 0.11±0.07μg·kg -1 wet tissue (P<0.01 or P<0.05) respectively. The levels of DOPAC in striatum,frontal contex and brain stem were decreased from 1.47±0.69,0.19±0.15, and 0.07±0.05 to 0.92±0.23,0.08±0.05,and 0.04±0.02μg·kg -1 wet tissue (P<0.01) respectively. The HVA levels in hippocampus and hypothalamus were raised from 0.01±0.00,0.03±0.02 to 0.04±0.03,0.07±0.05μg·kg -1 wet tissue (P<0.05), respectively. There were no obvious changes in DA,NE and MHPG levels. The raise of 5-HT contents may be related to the anesthetic activity of OMF.