雌激素受体与原发性肝癌生物学特性的关系

Estrogen receptor expression and its relationship with biologic feature in hepatocellular carcinoma

目的 为了探讨雌激素受体在原发性肝癌中的临床病理意义 ,对原发性肝癌的雌激素受体表达和原发性肝癌的生物学特性的关系作了研究。方法 用葡聚糖包裹活性炭吸附法检测了 62例原发性肝癌的雌激素受体表达 ,经大体和显微镜检查了这些原发性肝癌的病理特征 ,并用单克隆抗体PC- 10检测了这些肝癌的细胞增殖性核抗原 ( PCNA)。结果 雌激素受体阳性的肝癌 83.3%为单结节 ,58.3%有完整包膜 ,其构成比高于雌激素受体阴性肝癌的 4 2 .1%和 2 1.0 % ,统计学差异有显著性。小肝癌的雌激素受体阳性率 62 .5% ,显著高于大肝癌的 30 .4 % ( P<0 .0 5)。雌激素受体阳性肝癌的 PCNA标记指数为 ( 2 6.2± 18.7) % ,低于雌激素受体阴性肝癌的 ( 4 3.6± 32 .0 ) % ,统计学差异有显著性。结论 结果表明 ,雌激素受体阳性的肝癌与雌激素受体阴性的肝癌相比 ,前者的生物学行为和预后较好。

Objective For understanding the clinicopathologic significance of estrogen receptor (ER) in hepatocellular carcinoma (HCC) ER of the surgical resected species was detected and its relation to biologic feature was analysis. Methods ER was detected in 62 HCC species with Dextran coated charcoal method. Some pathologic characteristics were studied with gross and microscopic examination and proliferating cell nuclear antigen (PCNA) was determined with immunohistochemistry using monoclonal antibody PC 10. Results ER positive HCC had higher incidence of single nodule (83.3%) and complete encapsulation (58.3%) compared to ER negative HCC (42.1% and 21.0%). The difference was significant ( P <0 05). In small liver cancer ER positive rate was 62.5% which was higher than 30.4% in large liver cancer ( P <0 05). The PCNA labeled index was (26.2± 18.7)% in ER positive HCC and (43.6±32.0)% in ER negative HCC. The difference was significant ( P <0 05). Conclusion The results suggest that ER positive HCC has less malignant biologic behavior and better prognosis than ER negative HCC.