肝癌CT征象的时间生物学研究

The study of chronobiology of CT features of liver cancer

目的 通过 CT图像探索肝癌生长恶性生物学行为的生物周期特征 ,为研究肝癌治疗的药物敏感特异性时相提供依据。方法 确定 2 4种恶性生物学行为程度不同的 CT征象 ,每月随机抽样 30例 ,共 360例 ,列出每 1例出现的各种 CT征象 ,分别用一条余弦曲线拟合一组年周期数据进行时序特征分析 (余弦法 )。结果 数据统计学处理的置信值为 95% ,有 10种 CT征象显示生物节律特征 (〉<0 .0 5) ,归纳峰值相位参数发现 :肝癌生长侵袭性强的 CT征象集中在 - 60°～ - 12 0°( 3～ 4月份 ) ,非侵袭性生长的 CT征象集中在 - 180～ - 2 70°( 7～ 9月份 ) ,在 - 12 0°～ - 180°( 5～ 6月份 )和 -2 70°～ - 330°( 10～ 11月份 )则无峰值相位的参数出现。结论 肝癌生长的 CT表现存在侵袭性生长和非侵袭性生长 ,具有顺序性差异的生物周期模式。

Objective To explore the biological cycle of malignant biological behavior of liver cancer,and to provide a reseach basis for the excepically specific phase of drugs for clinical treatment of liver cancer.Methods 24kinds of CT features reflected varying degree of malignant biological behavior.There were 360 cases altogether from randam sampling 30 cases each month.The analytic method is each CT feature fitting a group data of yearly cycle using cosine curve made the analysis of the cyclic sequence character of each CT feature(cosinor).Results With 95% confidence,there were 10CT features which showed biologic rhythm( P <0 05).The acrophase of CT features for in vasive growth concentrated between-60° and-120°(March and April).But for non invasive growth,the CT features were relatively low and concentrated between-180°and-270°(July and September).No acrophase was shown in between-180°and -270°(July and September).No acrophase was shown in between-120°and-180°(May and June)and between-270°and-330°(October and November).Conclusion Between CT features of the invasive and non invasive growths of liver cancer,a sequential difference in biologic cycles can be observed.