期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

血管紧张肽受体拮抗药替米沙坦的进展 被引量：7

Telmisartan:a novel angiotensinⅡtype 1 receptor antagonist
下载PDF
导出
摘要 替米沙坦是一个新型的血管紧张肽Ⅱ受体1拮抗药,具有疗效显著、起效迅速、t_(1/2)长、不良反应少等优点。与其他沙坦类药物不同,替米沙坦尚有激活过氧化物酶体增殖激活受体的作用,在高血压治疗中可能略优于其他降压药物。 Telmisartan is a new angiotensln Ⅱ type 1 receptor antagonist with remarkable and quick effect, long half life and few adverse reactions. Different from other angiotensin Ⅱ receptor antagonist, telmisartan has the effect of modulating peroxisome proliferator-activated receptors, and might slightly superior to other anti-hypertensive drugs in the treatment of hypertension.
作者 黄震华
机构地区 上海交通大学医学院附属第九人民医院心血管病研究室
出处 《中国新药与临床杂志》 CAS CSCD 北大核心 2007年第7期544-548,共5页 Chinese Journal of New Drugs and Clinical Remedies
关键词 肾素-血管紧张肽系统 高血压 替米沙坦 rennin-angiotensin system hypertension telmisartan
分类号 R792.4 [医药卫生—临床医学]
  • 相关文献

参考文献21

  • 1KAKUTA H,SUDOH K,SASAMATA M,et al.Telmisartan has the strongest binding affinity to angiotensin Ⅱ type 1 receptor:comparison with other angiotensin Ⅱ type 1 receptor blockers[J].Int J Clin Pharmacol Res,2005,25(1):41-46.
  • 2STANGIER J,SU CA,van HEININGEN PN,et al.Inhibitory effect of telmisartan on the blood pressure response to angiotensin Ⅱchallenge[J].J Cardiovasc Pharmacol,2001.38(5):672-685.
  • 3SCHUPP M,JANKE J,CLASEN R,et al.Angiotensin type 1 receptor blockers induce peroxisome proliferators-activated receptor-γactivity[J].Circulation,2004,109(17):2054-2057.
  • 4BATFERSHILL AJ,SCOTF LJ.Telmisartan:a review of its use in the management of hypertension[J].Drugs,2006,66(1):51-83
  • 5FUJIMOTO M,MASUZAKI H,TANAKA T,et al.An angiotensin Ⅱ AT1 receptor antagonist,telmisartan augments glucose uptake and GLUT4 protein expression in 3T3-L1 adipocytes[J].FEBS Lett,2004,576(3):492-497.
  • 6BENSON SC,PERSHADSINGH HA,HO CI,et al.Identification of telmisartan as a unique angiotensin Ⅱ receptor antagonist with selective PPAR-gamma-modulating activity[J].Hypertension,2004,43(5):993-1002.
  • 7KOULOURIS S,SYMEONIDES P,TRIANTAFYLLOU K,et al.Comparison of the effects of ramipril versus telmisartan in reducing serum levels of high-sensitivity C-reactive protein and oxidized low-density lipoprotein cholesterol in patients with type 2 diabetes mellitus[J].Am J Cardiol,2005,95(11):1386-1388.
  • 8SHARPE M,JARVIS B,GOA KL.Telmisartan:a review of its use in hypertension[J].Drugs,2001,61(10):1501-1529.
  • 9GALZERANO D,TAMMARO P,del VISCOVO L,et al.Threedimensional echocardiographic and magnetic resonance assessment of the effect of telmisartan compared with carvedilol on left ventricular mass[J].Am J Hypertens,2005,18(12 pt 1):1563-1569.
  • 10PETROVIC J,PETROVIC D,VUKOVIC N,et al.Ventricular and vascular remodeling:effects of the angiotensin Ⅱ receptor blocker telmisartan and/or the angiotensin-converting enzyme inhibitor ramipril in hypertensive patients[J].J Int Med Res,2005,33(Suppl 1):39A-49A.

同被引文献58

引证文献7

二级引证文献25

中国新药与临床杂志
2007年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部