从头皮电位分布进行大脑皮层电位成像技术的仿真研究(英文)

A Simulation Study on Cortical Imaging Technique

用仿真的方法研究了根据头皮脑电分布重建大脑皮层电位分布的可行性。该方法采用三层媒质球作头的容积导体模型，利用最小范数的最小二乘法则估计头内一闭合的球型偶极层上偶极子的分布，然后根据估计结果重建大脑皮层电位分布。仿真结果表明，该方法可以很好地表现脑内不同深度源的活动情况；对于皮层脑电活动源，可以达到１ｃｍ的空间分辨率。

A computer simulation study was conducted to test the feasibility of cortical potential imaging. The inhomogeneous three concentric sphere head model was used to represent the head volume conductor. Closed spherical dipole layers, consisting of several thousand uniformly distributed dipoles, were used to reconstruct the cortical potential maps corresponding to neuronal sources located inside the brain. Simulation results indicate that the present procedure can image both cortical and deep sources, and for the cortical sources, a spatial resolution as high as 1 cm can be achieved.