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血浆可溶性白细胞分化抗原40配体对急性冠脉综合征患者近期预后判断的价值 被引量:2

The short-term prognostic value of soluble plasma CD40 Ligand in patients with acute coronary syndromes
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摘要 目的观察冠心病不同类型患者血浆中可溶性白细胞分化抗原40配体(sCD40L)的水平变化,评价血浆sCD40L对急性冠脉综合征患者(ACS)近期预后判断的价值。方法分别测定48例急性冠脉综合征(ACS)患者入院时血浆sCD40L水平,随诊3个月,并测定17例稳定型心绞痛及15例健康成人血浆sCD40L作对照。采用酶联免疫吸附试验测定血浆sCD40L水平,以血浆sCD40L>300 pg/m l为界值,追踪观察正常组与增高组心脏事件发生率。结果ACS患者血浆sCD40L水平(392.32±144.15)pg/m l显著高于SCHD组(282.57±56.13)pg/m l(P<0.01)和对照组(267.31±53.52)pg/m l(P<0.01),在48例ACS中,血浆sCD40L水平升高38例,随诊期共发生心脏事件20例,较血浆sCD40L水平正常组高(P<0.05)。结论急性冠脉综合征患者外周血浆sCD40L水平明显升高,可能与不稳定粥样斑块破裂密切相关,可作为动脉粥样硬化斑块不稳定的标志,sCD40L水平对判断急性冠脉综合征患者近期预后有较好的预测价值。 Objective To observe the changes of soluble plasma CD40 Ligand (sCD40L) level in different patients of coronary heart disease, and to evalute the short-term prognostic value of soluble plasma CD40 Ligand in pa- tients with acute coronary syndromes. Methods The study population included 48 cases of ACS patients,17cases of stable coronary heart disease (SCHD) patients and 15cases normal controls. Serum levels of sCD40L were measured by ELISA. With the kingdom of sCIMOL 〉 300 pg/ml, the normal group and the increased group were observed of the rate of cardiac events. Results Plasma level of sCD40L was significantly higher in patients with ACS (392.32 + 144.15 pg/ml )than in those of SCHD group (282.57 + 56.13 pg/ml ) (P 〈 0. 01 ) and normal control group (267.31 +53.52 pg/ml ) (P 〈0. 01 ). After the follow-up 3 month,38 patients had high sCD40L in 48 ACS patients with 20 patients having cardiac events. It were higher than the normal group ( P 〈 0. 05 ). Conehtsions Plasma levels of sCD40L can predict the short-term prognosis of patients with acute coronary syndromes.
作者 余强 马根山
出处 《中国临床保健杂志》 CAS 2007年第4期340-342,共3页 Chinese Journal of Clinical Healthcare
基金 江苏省卫生厅资助项目(wk0510)
关键词 冠状动脉疾病 CD40配体 动脉硬化 Coronary disease CI40 Ligand Arteriosclerosis
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  • 1[1]Bruemmer D,Riggers U,Holzmeister J,et al.Expression of CD40 in vascular smooth muscle cells and macrophages is associated with early development of human atherosclerotic lesions[J].Am J Cardiol,2001,87(1):21-27.
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