老年冠心病患者经皮冠状动脉介入术后联合应用阿司匹林和氯比格雷的安全性研究

Safety of combined application of clopidogrel and aspirin after percutaneous coronary intervention in old man

目的评价老年患者择期经皮冠状动脉介入治疗(PCI)术后联合应用氯比格雷和阿司匹林的安全性。方法随访因冠心病行择期PCI术的老年男性患者132例,所有患者PCI术后连续服用氯比格雷75 mg/d和阿司匹林100 mg/d,共12个月。观察患者服药期间主要心血管事件(急性或亚急性血栓形成、心绞痛、再发心肌梗死、心力衰竭、死亡等)及出血(严重出血、轻微出血)的发生率。应用16排螺旋CT复查冠状动脉造影。结果全部132例患者无心血管事件发生;仅3例出现消化道出血;冠脉CT检查未发现支架内再狭窄。结论老年患者PCI术后联合应用氯比格雷及阿司匹林可减少PCI术后心血管事件的发生,且副作用少。

Objective To investigate the safety of combined application of clopidogrel and aspirin after percutaneous coronary intervention in old man. methods All 132 male old patients after PCI operation were adminis- tered Clopidogrel and Aspirin for 12 months ,after the end of follow up,the occurrence rates of major myocardial ische- mia and hemorrhagic events were observed. CT were done to examine the cardiograph of conorary artery. Results there was no cases of heart events,but there was 3 cases of hemorrhage. Conclusion A long period of administration of combined application of clopidogrel and aspirin after percutaneous coronary intervention in old man was safe and effective.