21例小儿肺炎支原体肺炎免疫功能测定

Immune Function Test in 21 Children with Mycoplasma Pneumoniae Pneumonia

目的探讨小儿肺炎支原体肺炎(MPP)与机体免疫功能的关系。方法21例MPP患儿(病例组)在急性期和恢复期分别检测体液免疫功能(IgGI、gA、IgM、C3、C4,CH50)和细胞免疫功能(CD3+、CD4+、CD8+、CD4+/CD8+),同时以健康儿童20例作对照(对照组)。结果在急性期和恢复期,MPP患儿IgG均明显低于对照组(P<0.05),IgA、CD3+、CD4+、CD4+/CD8+均非常显著低于对照组(P<0.001),而C3、CH50则均非常显著高于对照组(P<0.001),急性期和恢复期机体免疫功能无明显差异。结论MPP患儿体液及细胞免疫功能处于明显低下状态,B细胞功能受损,T淋巴细胞亚群功能失调,补体系统被激活,患儿免疫功能恢复较慢,提高患儿机体免疫功能对MPP的防治具有重要的临床意义。

Objective To investigate the relationship with mycoplasma pneumoniae pneumonia（MPP） and cellular immunity in children. Method IgG, IgA , IgM, C3, C4, CH50 and T lymphocyte subpopulation were studied on acute stage and convalescence stage in 21 children with MPP. 20 healthy children served as normal controls. Results Among these subjects of MPP children both on acute stage and on convalescence stage,the level of IgG was significantly lower than that in control group（P〈0. 05）; IgA,CD3^＋ ,CD4^＋ ,CD4^＋/CD8^＋ were all significantly lower than those in control group （P〈 0. 001） ; C3 and CH50 were obviously higher than those in control group（P〈 0. 001）. There were no significant differences in immune function between acute stage and convalescence stage. Conclusions Both humoral immunity and cellular immunity in children with MPP are obviously low. B-lymphocyte function has been damaged. T lymphocyte subpopulation function is imbalance. Complement system has been activated. The immunity function recovers slowly in children patients. Raising immunity function has an important significance to prevent and treat MPP.