期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

尿Ⅳ型胶原测定对糖尿病肾病早期诊断的意义

Significance of Detection of Urine Type Ⅳ Collagen in Early Diagnosis of Diabetic Nephrosis
下载PDF
导出
摘要 目的探讨尿Ⅳ型胶原(Ⅳ-C)的检测在糖尿病肾病(DN)中的早期诊断价值。方法65例2型糖尿病(DM)患者根据尿白蛋白排泄率(UAER)分为正常白蛋白尿组(DM1)、微量白蛋白尿组(DM2)和大量白蛋白尿组(DM3),检测各组尿Ⅳ-C及尿微量白蛋白(MA)含量,并与42例正常对照组(NC)进行比较。结果DM患者尿Ⅳ-C含量显著高于NC组(P<0.05),且尿Ⅳ-C在DM 1、2、3组间呈逐组增高趋势,均有显著差异(P<0.01),尿Ⅳ-C与UAER呈显著正相关(P<0.01)。结论尿Ⅳ-C测定可作为DN早期诊断更有用的指标。
作者 胡怀霞
机构地区 连云港市第二人民医院肾内科
出处 《现代诊断与治疗》 CAS 2007年第4期213-214,共2页 Modern Diagnosis and Treatment
关键词 糖尿病肾病 Ⅳ型胶原 尿微量白蛋白
分类号 R587.2 [医药卫生—内分泌]
  • 相关文献

参考文献4

  • 1Kotajima N,Kimura T,Kanda T,et al.Type Ⅳ collagen as an early marker for diabitic nephropathy in non-insulin-dependent diabetes mellitus[J].J Diabetes Complications,2000,14:13-17.
  • 2Cohen MP,Ziyadeh FN,Lautenslager GT,et al.Glycated albumin stimulation of PKC-beta activity is linked to increased collagen Ⅳ in mesangialcells[J].Am J Physiol,1999,276:684-690.
  • 3李丹清.胶原代谢与糖尿病肾病[J].国外医学（内分泌学分册）,2002,22(3):188-191. 被引量：6
  • 4Tomino Y,Suzuki S,Azushima C,et al.Asian multicenter trials on urinary type Ⅳ collagen in patients with diabetic nephropathy[J].J Clin Lab Anal,2001,15(4):188-192.

二级参考文献12

  • 1Lupia E, Elliot S J, Lenz O.IGF-1 decreases collagen degrad ation in diabetic NOD mesangial cells: implications for diabetic nephropathy[J ].Diabetes,1999,48:1638-1644.
  • 2Cohen M P, Ziyadeh F N, Lautenslager G T, et al.Glycated alb umin stimulation of PKC-beta activity is linked to increased collagen Ⅳ in mes angial cells[J].Am J Physiol,1999,276:(5 pt 2):F684-F690.
  • 3Yang C W, Vlassara H, Striker G E, et al.Administration of AGEs i n vivo induces genes implicated in diabetic glomerulosclerosis[J].Kidney Int,1995,47(suppl 49):S55-S58.
  • 4Cohen M P, Masson N, Hud E, et al.Inhibiting albumin glycation am eliorates diabetic nephropathy in the db/db mouse[J].Exp Nephrol,2000,8:13 5-143.
  • 5Heilig C W, Concepcior L A, Riser B L, et al.Overexpression of gl ucose transporters in rat mesangial cells cultured in a normal glucose milieu mi mics the diabetic phenotype[J].J Clin Invest,1995,96:1802-1814.
  • 6Kotajima N,Kimura T,Kanda T,et al.Type Ⅳcollagen as an e arly marker for diabetic nephropathy in non-insulin-dependent diabetes mellitu s[J].J Diab Compl,2000,14:13-17.
  • 7Watanabe H, Sanadn H, Shigetomi S, et al.Urinary excretion o f type Ⅳ collagen as a specific indicator of the progression of diabetic nephro pathy[J].Nephron,2000,86:27-35.
  • 8Sumida Y, Ura H, Yano Y, et al. Abnormal metabolism of type -Ⅳ in normotensive non-insulin-dependent diabetes mellitus patients[J].Horm Res,1997,48:23-28.
  • 9Yagame M, Kim Y, Zhu D, et al.Differential distribution of t ype Ⅳ collagen chains in patients with diabetic nephropathy in non-insulin-de pendent diabetes mellitus[J].Nephron,1995,70:42-48.
  • 10Adler S G, Feld S, Striker L, et al. Glomerular type Ⅳ coll agen in patients with diabetic nephropathy with and without additional glomerula r disease[J].Kidney Int,2000,57:2084-2092.

共引文献5

现代诊断与治疗
2007年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部