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Etanercept及其在血液病中的应用

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摘要 大量研究表明肿瘤坏死因子在多种炎性疾病及血液病的发病机制中扮演一定的角色。因此,作为一种肿瘤坏死因子拮抗剂Etanercept,为这些疾病,尤其是一些难治复发血液病的治疗提供了一种新的选择。本文就Etanereept的药理作用、安全性及其在多种血液病中的应用作一介绍。
出处 《国际输血及血液学杂志》 CAS 2007年第4期358-361,共4页 International Journal of Blood Transfusion and Hematology
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  • 1Tsimberidou AM, Waddelow T, Kantarjian HM, et al. Pilot study of recombinant human soluble tumor necrosis factor (TNF) receptor (p75) fusion protein (TNFR: Fc; Enbrel) in patients with refractory multiple myeloma., increase in plasma TNF alpha levels during treatment. Leuk Res, 2003,27 (5) : 375-380.
  • 2Tsimberidou AM, Thomas D, O'Brien D, et al. Recombinant human soluble tumor necrosis factor (TNF) receptor (p75) fusion protein Enbrel in patients with refractory hematologic malignancies. Cancer Chemother Pharmacol, 2002, 50 ( 3 ):237- 242.
  • 3Mohler KM, Torrance DS, Smith CA, et al. Soluble tumor necrosis faetor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and funetion simultaneously as both TNF carriers and TNF antagonists. J Immunol, 1993, 151 (3): 1548- 1561.
  • 4Tsimberidou AM, Giles FJ. TNF-α targeted therapeutic approaches in patients with hematologic malignancies. Expert Rev Anticancer Ther, 2002,2 (3) : 277- 286.
  • 5Stone JH, Uhlfelder ML, Hellmann DB, et al. Etanercept combined with conventional treatment in Wegener's granulomatosis: a six-month open-label trial to evaluate safety.Arthritis Rheum, 2001,44(5):1149-1154.
  • 6Bozkurt B, Torre-Amione G, Warren MS, et al. Results of targeted anti-tumor necrosis factor therapy with etanercept (Enbrel) in patients with advanced heart failure. Circulation,2001,103(8):1044-1047.
  • 7Lebwohl M, Blum R, Berkowitz E, et al. No evidence for increased risk of cutaneous squamous cell carcinoma in patients with rheumatoid arthritis receiving etanercept for up to 5 years. Arch Dermatol, 2005,141(7) :861-864.
  • 8Gersuk GM, Beckham C, Loken MR, et al. A role for tumour necrosis factor-α, Fas, and Fas-ligand in marrow failure associated with myelodysplastic syndrome. Br J Haematol, 1998,103(1):176-188.
  • 9Deeg HJ, Gotlib J, Beckham C, et al. Soluble TNF receptor fusion protein (etanercept) for the treatment of myelodysplastic syndrome: a pilot study. Leukemia,2002,16(2):162-164.
  • 10Deeg HJ ,Jiang PY,Holmberg LA,et al. Hematologic responses of patients with MDS to antithymocyte globulin plus etanercept correlate with improved flow scores of marrow cells. Leuk Res,2004,28(11):1177-1180.

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